FDA Approves “Female Viagra” Addyi

The experimental drug flibanserin, made by Sprout Pharmaceuticals, is at the center of a regulatory controversy.

The experimental drug flibanserin, made by Sprout Pharmaceuticals, is at the center of a regulatory controversy.

Yesterday, the Food and Drug Administration (FDA) approved Addyi (also known by its generic name Flibanserin) for public consumption. The drug, produced by Sprout Pharmaceuticals, is being touted as a “female Viagra,” a way to “even the score” sexually against men (who have many option to treat waning sexual desire). In some circles, it’s seen as a big breakthrough for women’s sexual health.

Interestingly, Addyi is the first drug to specifically treat waning sex drives for both men and women. (Viagra solved a purely medical/physical issue rather than a psychological one.) Addyi targets the central nervous system, putting it in line with an antidepressant.

Addyi purports to help women with hypoactive sexual disorder (i.e. lack of sexual desire.) But it works on a woman’s mind instead of her body. Rather than facilitating blood flow to the genital region, as Viagra does, the drug takes a two-pronged approach:

Flibanserin targets two neurotransmitters in the brain that can help inspire sexual desire. The first is dopamine, which helps control the brain’s reward and pleasure centers and could help drive up our interest in sex. The second is norepinephrine, which affects parts of the brain that control our attention and our response to things in our environment and could help direct our attention to a sexual partner.

The ultimate goal is that a woman’s level of desire would increase over time.

(Side note: Apparently, Viagra was marketed to women in 2004. The drug did increase blood flow to the women’s genitals, but didn’t affect their level of sexual desire.)

But the drug isn’t completely out of the woods yet: there are still some concerns regarding side effects. Doctors and pharmacists will need to undergo specific training of the drug before dispensing it, and will need to keep track of the women who take it. The biggest side effects include low blood pressure, sleepiness and “sudden fainting,” especially when taken with alcohol. (I have to say, I don’t really understand the point of making a drug to help with sex that can’t be paired with alcohol, but that’s just me.)

There’s also an argument that the drug “doesn’t work safely enough to justify its approval:” Women who took the drug during clinical trials reported a 37% increase in sexual desire, which averaged out to not even two more “satisfying sexual experiences” per month. The boost over the placebo group was even smaller.

It’s expected that Addyi will be covered under most health insurance plans, requiring a co-pay, and will inhabit a price range similar to that of Viagra. The drug should hit the market as soon as October (i.e. less than two months), with some outlets reporting an exact date of Oct. 17th.

I have to say, I’m really curious to see how this will do. I want to see how well it’ll perform (heh) sales-wise, and how many women report the side effects. But most of all, I want to see how this drug will influence the female-desire drugs that will surely come after it.

What’s the Most Dangerous Sex Position?

Girl on top (Ethnic Health Court)

Girl on top (Ethnic Health Court)

Happy Friday! Time for a Sex & Stats PSA: This weekend, as you’re getting it on with your partner(s), remember that some positions are more dangerous than others. (But that makes them more exciting, right?) Scientists have recently discovered that girl-on-top sex is the most dangerous position for men.

How did they discover this, you ask? Scientists in Campinas, Brazil (a city northwest of Sao Paolo) examined patients from three local hospitals to study penile fractures and their long-term influence on potential future deformities and erectile and voiding issues.

According to “Advances in Urology,” 42 of the 44 “suspicious cases” (95%+ of the total) were confirmed to be penile fractures. The mean age of the men was 34+ years.

The abstract notes that many of the men presented certain, um, signs of fracture:

Half presented the classical triad of audible crack, detumescence (i.e. becoming flaccid), and pain.

(I totally grimaced just typing that. And I’m a woman.)

The researchers found that most penile fractures resulted from heterosexual intercourse, which happened in 66%+ of the subjects. By contrast, homosexual sex brought on fractures only with 9%+ of subjects.

Now, the good stuff: With heterosexual couples, “woman on top” was the most common position, with 14 participants, exactly 50% of the pool. “Doggy style” was the next most common, with a sample size of eight participants, at 28%+. Four subjects reported that the cause of fracture was “unclear,” which sounds like they did a variety of things that, combined, led to the fracture, or were just too embarrassed to report their activities.

The researchers’ hypothesis on why cowgirl is so dangerous boils down to the fact that women can better control the movement, with her body weight resting on the penis. In this position, men are more liable to injury since they can’t control or stop the movement, and they have the potential for greater injury as a result of “wrong-way penetration.”

Let’s review: 42 cases of penile fracture. 28 people/14 couples participating in heterosexual coitus. “Woman on top” has a full 50% chance of resulting in penile fractures.

So go out and have fun, but don’t end up in the emergency room.

How Common Is Vaginismus?

Vaginal Dilators

Vaginal Dilators

If you haven’t heard the term, “vaginismus” refers to vaginal tightness during, or even preventing, sexual intercourse. It’s not widely talked about, but it definitely exists.

But how many women suffer from it.

Vaginismus.com estimates that it affects roughly every 2 in 1K women. In the US, as of the 2010 census, that amounts to 313K+ women, assuming it has an equal distribution, or affects women of all ages equally.

But since it’s such a private matter, and women may be ashamed and/or embarrassed to speak up about it, there’s no way to get a firmer number.

Other statistics cited on the page estimate that vaginismus occurs more often in women ages 15-24, since attempted first intercourse generally falls within that range. The Masters & Johnson Institute and the Center for Human Sexuality put the rate of vaginismus in their patients at 20% and 40%, respectively.

Period Sex: Who’s Doing It?

Splattergore

Splattergore

“The Cut” published an article yesterday on period sex. While the overall excellent article was long on anecdotes, it lacked what I love: hard stats!

How many women are having period sex? It’s the thing we dread will ruin our steady dates and hot hookups, but some women have figured out that it doesn’t have to be that way.

In 2011, menstrual cup company Softcup released a survey that uncovered, among other things, how much a woman’s perdio affects her sex life. The survey found that 60% of all women are uncomfortable with period sex. It showed an age disparity: 70% of older women (ages 45-54) were uncomfortable, while only 51% of younger women (ages 18-34) were.

(I don’t know where women ages 35-44 disappeared to.)

It’s clear that the majority of women haven’t gotten into period sex. But based on the “NYMag” article, the men are having more fun than ever.